Resurrecting the intestinal microbiota to combat antibiotic-resistant pathogens

Intestinal Microbiota in the Control of Pathogens

The intestinal mucosa contains innumerable species of commensal microorganisms, at equilibrium end up preventing the persistence of or even eliminating pathogenic microorganisms. The manner by which the intestinal microbiota eliminates pathogenic microorganisms has been extensively studied by diverse researchers throughout the world. This is mainly due to the fact that the indiscriminate use of...

Repurposing Clinical Molecule Ebselen to Combat Drug Resistant Pathogens

Without a doubt, our current antimicrobials are losing the battle in the fight against newly-emerged multidrug-resistant pathogens. There is a pressing, unmet need for novel antimicrobials and novel approaches to develop them; however, it is becoming increasingly difficult and costly to develop new antimicrobials. One strategy to reduce the time and cost associated with antimicrobial innovation...

Engineering Synthetic Bacteriophage to Combat Antibiotic-Resistant Bacteria

Antibiotic resistance is a rapidly evolving problem that is not being adequately met by new antimicrobial drugs. Thus, there is a pressing need for effective antibacterial therapies that can be adapted against antibiotic-resistant bacteria. Here, we engineered synthetic bacteriophage to combat antibiotic-resistant bacteria by overexpressing proteins and attacking gene networks which are not dir...

Synthetic Biology Approaches to Combat Antibiotic Resistant Bacteria

Synthetic biology (SB) is an innovative and emerging field, representing a confluence of science and engineering. It aims to (re)-design biological parts, devices and systems while applying engineering principles for useful applications. Valuable insight gained on the functions of biological systems will further improve the design capacity. The advance of SB is expected to provide solutions to ...

Strategies to Combat Antibiotic Resistance